Anti-VHLL Antibody
Cat. No.
Y158438
Unit
100 μl
Price
$152.00
Specifications
| Cat. No. | Y158438 |
| Name | Anti-VHLL Antibody |
| Clone | Polyclonal |
| Price | $152.00 |
| Unit | 100 μl |
| Category | Polyclonal Antibodies |
| Application | WB,ELISA |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human |
| Description | Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010] |
| Immunogen | Rabbit polyclonal VHLL (1) antibody was raised against a recombinate human VHLL protein 1-139aa (BC130596). |
| Concentration | 100ug/100ul |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-VHLL Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Depositor | SaierBio |
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