Anti-Tyrosine Kinase Receptor B (TrkB, 23-36) Antibody

Cat. No.

Y075047

Unit

100 μl

Price

$560.00

Specifications

Cat. No.	Y075047
Name	Anti-Tyrosine Kinase Receptor B (TrkB, 23-36) Antibody
Price	$560.00
Unit	100 μl
Category	Polyclonal Antibodies
Gene Name	Tyrosine Kinase Receptor B
Application	IHC
Application Info	A dilution of 1:1000 to 1:3000 is recommended for this application. The optimal working dilution should be determined by the end user. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics.
Raised In	Rabbit
Clonality	Polyclonal
Reactivity	Human,Rat
Description	FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE products_recover: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain.
Immunogen	A synthetic peptide (AFPRLEPNSIDPENC) as part of rat mature TrkB protein (aa: 23-36) conjugated to KLH
Concentration	1ug/ul
Recommended Dilutions	A dilution of 1:1000 to 1:3000 is recommended for this application. The optimal working dilution should be determined by the end user. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics.
Storage Buffer	PBS, pH 7.4 with 0.02% sodium azide.
Storage Condition	This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Formulation	Liquid
Species Reactivity	Human,Rat
Specificity	Sequence was chosen to avoid cross reactivity with TrkA and TrkC.
Purity	Filter purified
Guarantee	abm guarantees that all our Anti-Tyrosine Kinase Receptor B (TrkB, 23-36) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Depositor	Biosensis

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