Anti-RAR alpha Antibody
Cat. No.
Y058256
Unit
100 μl
Price
$152.00
Specifications
| Cat. No. | Y058256 |
| Name | Anti-RAR alpha Antibody |
| Clone | Polyclonal |
| Price | $152.00 |
| Unit | 100 μl |
| Category | Polyclonal Antibodies |
| Gene Name | RARA |
| Alias | RAR, NR1B1 |
| Application | WB,IHC,ELISA |
| Application Info | For research use only Peptide ELISA titer: 1:40,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use. |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Description | Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]). |
| Immunogen | Rabbit polyclonalRAR alpha (1) antibody was raised against a 15 amino acid peptide from near the C terminal residues of human retinoic acid receptor alpha protein. |
| Isotype | IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions | For research use only Peptide ELISA titer: 1:40,000 Western blot analysis: 1:200-1000 Immunohistochemistry: 1:50-200 Optimal dilutions/concentrations should be determined by the end use. |
| Storage Buffer | PBS, pH 7.4 with 0.02% Sodium Azide |
| Storage Condition | This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human,Mouse,Rat |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-RAR alpha Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Depositor | SaierBio |
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