Anti-KCNE3 (MiRP2) Antibody

Cat. No.

Y059873

Unit

50μl

Price

$935.00

Specifications

Cat. No.	Y059873
Name	Anti-KCNE3 (MiRP2) Antibody
Clone	Polyclonal
Price	$935.00
Unit	50μl
Category	Polyclonal Antibodies
Gene Name	KCNE3 (MiRP2)
Application	WB,IHC
Application Info	Western Blotting: Rat kidney and heart membranes (1:200). Immunohistochemistry: Rat kidney sections.
Raised In	Rabbit
Clonality	Polyclonal
Reactivity	Rat
Description	K+ channel β subunit MiRP2, MinK-related peptide 2 KCNE3 (or MiRP2) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KCNE1( IsK, MiNK), KCNE2 (MiRP1), KCNE4 (MiRP3) and KCNE5 (MiRP4). KCNE1 is the founding member of the family and was initially believed to form a K+ channel itself, but was latter recognized that it worked as a regulatory b subunit associated with the Kv7.1 (KCNQ1) a protein. KCNE3 was discovered based on its homology with KCNE1. The KCNE regulatory subunits are small proteins (14- 20 kD) with a type-1 integral membrane topology. It is believed that both the cytoplasmic C-terminus tail and the transmembrane domain are necessary for the interaction with the a subunits. The stoichiometry of the KCNE subunits with their partner a subunits in the native channels is not clear and ratios ranging from 2 to 14 KCNE subunits per 4 a subunits have been proposed. KCNE3 is relatively widely expressed in several tissues with prominent expression in the kidney and skeletal muscle. KCNE3 is quite promiscuous and associations with Kv7.1, Kv3.4, Kv7.4 (KCNQ4), Kv11.1 (HERG), Kv2.1 and Kv3.1b have been demonstrated. The best characterized interactions are with the former two proteins. KCNE3 interacts with Kv7.1 in epithelial cells of the gastrointestinal tract where it appears to be important for Na+ absorption. In skeletal muscle KCNE3 couples to Kv3.4 to regulate muscle function. Indeed, a mutation in KCNE3 (R83H) has been associated with an inherited form of periodic paralysis (Thyrotoxic hypokalemic periodic paralysis).
Immunogen	Peptide (C)RSRKVDKRSDPYH, corresponding to amino acid residues 81-93 of human KCNE3 (Accession Q9Y6H6 ).
Concentration	1ug/ul
Recommended Dilutions	Western Blotting: Rat kidney and heart membranes (1:200). Immunohistochemistry: Rat kidney sections.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Storage Condition	This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Formulation	Liquid
Species Reactivity	Rat
Specificity	Rat, mouse, dog, pig- identical
Purity	Affinity purified on immobilized antigen.
Guarantee	abm guarantees that all our Anti-KCNE3 (MiRP2) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Depositor	Alomone Labs Ltd

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